Allen Iverson also scored 19 for Detroit (11-6), which has won two of its last three games. Richard Hamilton scored 16 points and Tayshaun Prince added 15 for the Pistons, who are 5-2 against the Spurs since losing the 2005 NBA Finals in a seven-game series.
The Spurs (9-8) have dropped two straight games after winning four in a row. They were led by Tim Duncan, who had 23 points but just one in the fourth quarter.
Ginobili scored 13 in his first start of the season after missing the first 12 games because of offseason ankle surgery.
The Pistons, who trailed by 10 twice in the third, finally pulled ahead when Wallace hit a 3-pointer almost four minutes into the fourth. He hit two more 3s in the fourth as Detroit outscored the Spurs 28-14.
Iverson trimmed the Spurs’ 50-40 lead less than two minutes into the third down to 52-50 on a layup with 7:18 remaining in the period.
But San Antonio scored eight straight, capped by Bruce Bowen’s 3 with 3:14 left in the third, to go ahead 60-50 with 3:14 left in the third.
Iverson’s 3 cut the Spurs’ lead to one point, but Ginobili came back down the floor and quickly hit his own 3. San Antonio clung to a 63-61 lead heading into the fourth.
After starting the game 4-of-5 for a two-point lead, the Pistons went 1-of-7 during the next 5:22 and the Spurs held their largest lead of the quarter at 16-10.
Iverson, who played the entire first quarter for seven points on 3-of-5 shooting, got Detroit back on track with a 3 to cut San Antonio’s lead to 16-13 with 3:42 to go. But the Spurs led by five heading into the second quarter.
San Antonio led by as many as seven points in the second quarter before the Pistons scored 12 consecutive points during a stretch of 3:28. The run consisted of a pair of free throws and five straight layups. The last two were slam dunks by Jason Maxiell that gave Detroit a 31-26 lead with 7:10 left in the first half.
