The Oklahoma quarterback injured his right, throwing shoulder twice this season, most recently against Texas on Oct. 10.
The school announced Sunday that Dr. James Andrews will perform the operation Wednesday in Birmingham, Ala. Bradford is expected to address reporters following the Sooners' practice on Monday night.
"I dreamed about coming to Oklahoma my whole life," Bradford said Sunday in a statement. "That's the reason I came back for this season. And I came back to play, not sit on the bench. That's the reason I tried to play after the injury. I'm very disappointed that it didn't work out differently.
"Under these circumstances, and after talking to several people, this is the right thing for me to do at this point."
Bradford passed up the chance to be a first-round NFL draft pick this year - he was projected as high as No. 1 overall - to play another season with the Sooners, who he grew up following as a child in Oklahoma City.
